The Benefits of Macrodosing
Macro-dosing is typically for those who are looking to get more of a buzz than just micro-dosing but without eating the actual mushroom itself. Taking the capsules saves you from the taste of the mushroom product it self.
For starters, psilocybin and LSD share a very similar molecular structure to serotonin, one of the brains ‘feel good’ chemicals.

In addition to this, those who have ingested psychedelics on the sub-perceptual level (myself included) have attested to experiencing:
- Heightened creativity
- Reduction in anxiety
- Greater sense of pressecense
- Heightened awareness
- Increased productivity
There are also studies that suggest psychedelic use increases and expands communication within the brains neural network and even encourages neurogenesis (the growth and development of new and pre-existing brain cells).
The benefits commonly attributed to macrodosing are all similar effects experienced while in ‘flow’ or ‘flow state’, making it seem likely that habitualy consuming sub-perceptual doses of psychedelics can shift your brain to a more regular state of flow.
How to Macrodose
Ideally, a psilocybin microdose will not cause a substantial change in mood, disposition, or mindset. Instead, its effect will be subtle but present.
Not only will fresh and dried psilocybin mushrooms contain different quantities of psilocybin, but different strains of mushrooms will have different psychoactive contents. Even different parts of the mushroom contain slightly different amounts of psilocybin.
You can use any kind of psilocybin mushrooms for your macrodosing. The most popular are Psilocybe cubensis, Psilocybe semilanceata, Psilocybe azurecens, Psilocybe cyanescens, and Panaeolus. You can learn about the potency levels of different Psilocybe strains at Erowid.
There are several ways to take your mushroom macrodose. The most practical one is to take your capsule with food. Another way is to prepare a psilocybin tea. You can dissolve your capsule of mushroom powder in hot water, and even add some honey. Otherwise, you are free to experiment and mix the powder into any drink you take to start your day.
What Schedule Should I Follow?
James Fadiman recommends taking a macrodose once every three days. For most people, morning is the best time because the beneficial effects will last throughout the day, and also because nighttime microdosing could interfere with sleep.
Take a mushroom macrodose on Day 1. Then do not take a macrodose on Day 2 or Day 3.
Then, take another mushroom macrodose on Day 4.
Observe the effects throughout this process by taking daily notes in a journal.
Continue the process of macrodose two times per week for several weeks. Take notes throughout the entire process on both short-term, in-the-moment effects, and long-term changes in your mood, energy, and social behavior.
Follow your usual routine while macrodose. You should not change what you do. The purpose is to enhance your day-to-day existence by integrating macrodose into your routine.
Ingredients in Psilocybe Cubensis Macrodose Stack:
300 mg of grinded Golden Teachers Psilocybin Mushrooms
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