Mushrooms teach us all some of the most important affecting lessons if we are truly listening to the Mycelium Intelligence. After having consumed more than a few kilograms during the course of my life, and having been on hundreds of mushrooms journeys, here are three of the most important lessons that the mushroom has taught me about itself.
Psilocybin Mushrooms Work Best On An Empty Stomach
The primary chemical in Magic Mushrooms responsible for hallucinogenic and entheogenic activity is Psilocybin which is a Serotonin analog.
Serotonin is produced in the brain and the intestines. Most of the serotonin in the body (roughly 80-90%) can be found in the gastrointestinal tract. The next highest concentration is in the muscular system, blood platelets, and finally the brain.
The reason is elementary: Psilocybin is a potent serotonergic agonist which causes strong gastric activity. Since serotonin is primarily located in the gastric system, when you take mushrooms the gut pretty much wants to expel what it contains since it is being highly agonized. This can cause some people to become nauseated and many people have reported nausea and or having to go to the restroom after taking a moderate dose.
How Are Serotonin, Nausea, and Bowel Movements Linked?
Serotonin is primarly produced and used by the gastric system. Serotonin and our gastric systems are deeply linked. Most of our nervous system functions on serotonin.
Why do mushrooms cause upset stomach?
Serotonin is most abundantly found in the gastrointestinal tract. The function of serotonin there is to regulate bowel movements.
Higher doses of mushrooms cause a greater effect in the gut. I’ve discovered that Psilocybin mushrooms work best when taken on an empty stomach.
Why Do Mushrooms Cause Nausea
Upon the ingestion of anything slightly toxic, the gut begins to produce more serotonin. When the gut is irritated, more serotonin is produced which causes the gut to expel what it contains.
Extremely high doses of mushrooms when consuming on a full stomach can cause irritant diarrhea. According to a study regarding the action of serotonin on the gastrointestinal tract, “blood serotonin levels are naturally reduced as a reaction which also causes nausea by stimulating the nausea area in the brain.”
“Selective serotonin 5-HT3 receptor antagonists have proven safe and effective for the management of postoperative nausea and vomiting.” This is why serotonin angtagonists are prescribed for severe or deblitating nausea and some gastric issues.
Because of the activity of serotonin in the gut, the gut has come to be known as the second brain of the body. This is another symbolic reason why it is important to empty that second “brain or mind” before we ingest magic mushrooms. Otherwise, the gut will try to expel what it contains either through vomiting or through a bowel movement.
It is not necessary to fast, but it can be helpful. It is important to keep the stomach empty for at least 6-8 hours before taking mushrooms.